Anaplastic Large Cell Lymphoma – Symptoms, Survival Rate, Treatment


Lymphoma is the most common form of Cancer. The prime reason behind the Lymphoma is the abrupt cell division and increase of the immune cells. Immune cells are also known as White Blood Cells. Anaplastic Large Cell Lymphoma is a Non Hodgkin kind of Lymphoma in which the T Cells get affected. The rare type of Lymphoma can become fatal as it has the capability to travel to any location including lymph nodes, blood, and various organs. The seriousness of this Lymphoma increase when tumor is formed in the body.

Anaplastic Large Cell Lymphoma or ALSL has two stages. In the primary stage, it remains within the skin. This stage is called Primary Cutaneos Lymphoma. It is usually slow growing Lymphoma and does not spread at rapid speed. However, at the second stage, ALCL becomes very rapid and it reaches various organs.

Symptoms of Anaplastic Large Cell Lymphoma

ALCL starts showing the symptoms late in the body. That is why it becomes more dangerous to diagnosis the disease. However, it is important to understand the Symptoms very carefully. Any similar symptoms in the body should immediately addressed.

  • Lumping of Neck is the most common symptom noticed in ALCL. The symptom can be observed very early for the ALCL.
  • Armpit Lumping, Groin Lump are also very common in Anaplastic Large Cell Lymphoma.
  • Tiredness would be very common in this syndrome, if you are feeling tired often and tiring soon, then you might be diagnosed with ALCL.
  • You would lose your appetite along with Sweats at night are also very frequent with ALCL.
  • Temperature of the body might increase abruptly and loss of weight could become prominent in life with the presence of ALCL.
  • However, in the early stage, you might not find any symptom at all for this syndrome, but with the progress of the lymphoma, you may encounter Skin Lumping as the early sign in the Primary Cutaneos Stage.

Diagnosis of Anaplastic Large Cell Lymphoma

Diagnosis of ALCL needs extensive study and research. The medical history and the past record of the patient must be taken into consideration. However, the lymph node movement, Oraganomegaly, and cutenous presence are also closely observed. But the most important and crucial finding that indicates the Anaplastic Large Cell Lymphoma are the presence of T-Cell Antigens in the body along Anaplastic Lymphoma Kinase Protein. Both the element can very well indicate the ALCL. However, crucial tests like Computed Axial Tomography (CAT), Magnetic Resonance Imaging (MRI), and Positron Emission Tomography (PET) are used to determine the Anaplastic Large Cell Lymphoma.

Treatment of Anaplastic Large Cell Lymphoma

The major problem with ALCL is, it has the chances of relapse. The high risk syndrome is first treated with low intensity Chemotherapy. The initial stage of first time ALCL and relapsing stage respond very well to the treatment. However, as the situation worsens, the dose of the Chemotherapy increases.



Apart from it, radiation, tropical treatments, biologic therapies and systematic treatment are quite successful. Systematic Therapy is very useful for the condition in which ALCL spreads in multiple positions, in the body.  It has been noticed that for very high level of ALCL, along with ALCL, Stem Cell Transplantation is advised. Apart from all the traditional and common treatments for ALCL, new treatments have also been very successful in recent times. Treatments like Bortezomib, Brentuximab Vedotin, Crizotinib and Pralaxtrexate are the most common of treatments.

Survival Rate of Anaplastic Large Cell Lymphoma

The Survival Rate and success of treatment depends upon majorly two things, nature and type of ALCL and the age of the patient. If the ALCL extends beyond skin then the nature of the ALCL becomes very serious. However, only 10% of times, ALCL does that. But another crucial factor Anaplastic Lymphoma Kinase Protein impacts the survival rate a lot. It has been noticed that a person with Anaplastic Lymphoma Kinase in ALCL responds better to treatment. But the best thing about that is it reduces the chance of relapsing by considerable amount and increases the chance of survival by almost 70%. With the age, ALCL survival changes and it has been noticed that Children and people aged over 60 are more susceptible to Anaplastic Large Cell Lymphoma.


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